time travel

January 28, 2007

Milky Way Black Hole May Be a Colossal ‘Particle Accelerator’

Filed under: Space — travel @ 8:51 am

Scientists were startled when they discovered in 2004 that the center of our galaxy is emitting gamma rays with energies in the tens of trillions of electronvolts.

Now astrophysicists at The University of Arizona, Los Alamos National Laboratory and the University of Adelaide (Australia) have discovered a mechanism that might produce these high-energy gamma rays. The black hole at the center of our Milky Way could be working like a cosmic particle accelerator, revving up protons that smash at incredible speeds into lower energy protons and creating high-energy gamma rays, they report.

“It’s similar to the same kind of particle physics experiments that the Large Hadron Collider being built at CERN will perform,” UA astrophysicist David Ballantyne said.

When complete, the Large Hadron Collider in Switzerland will be able to accelerate protons to seven trillion electronvolts. Our galaxy’s black hole whips protons to energies as much as 100 trillion electronvolts, according to the team’s new study. That’s all the more impressive because “Our black hole is pretty inactive compared to massive black holes sitting in other galaxies,” Ballantyne noted.

Ballantyne collaborated with UA astrophysics Professor Fulvio Melia in the new study published in Astrophysical Journal Letters.

For the last several years, Melia has been developing a theory of what may be going on very close to the Milky Way’s black hole. Melia and his group find that powerful, chaotic magnetic fields accelerate protons and other particles near the black hole to extremely high energies.

“Our galaxy’s central supermassive object has been a constant source of surprise ever since it’s discovery some 30 years ago,” Melia said. “Slowly but surely it has become the best studied and most compelling black hole in the universe. Now we’re even finding that its apparent quietness over much of the spectrum belies the real power it generates a mere breath above its event horizon—the point of no return.”

The Milky Way black hole “is one of the most energetic particle accelerators in the galaxy, but it does this by proxy, by cajoling the magnetized plasma haplessly trapped within its clutches into slinging protons to unearthly speeds,” Melia said.

Ballantyne used detailed, realistic maps of interstellar gas extending 10 light years beyond the black hole in modeling whether accelerated protons launched from the galactic center would produce gamma rays.

“We calculated very exactly how the protons would travel in this medium, taking into account specifically the magnetic force that changes the protons’ trajectories,” he said. The team calculated 222,000 proton trajectories for a statistically solid study.

Even though the protons move close to the speed of light, their motion is so random that it takes several thousand years for the particles to travel beyond 10 light years of the black hole. After the high-energy protons escape the black hole environment, they fly off into the interstellar medium, where they collide with low-energy protons (hydrogen gas) in a smash-up so energetic that particles called ‘pions’ form. These particles of matter quickly decay into high-energy gamma rays that, like other radiation, travel in all directions.

Ballantyne, Melia and and their colleagues found that this process can explain the energy spectrum and brightness of gamma-ray emission that astronomers observe. Researchers detect the high-energy gamma-ray emission with ground-based telescopes at Namibia, Africa, at Whipple Observatory in southeastern Arizona, and elsewhere.

“Ironically, even though our galaxy’s central black hole does not itself abundantly eject hyper-relativistic plasma into the surrounding medium, this discovery may indirectly explain how the most powerful black holes in the universe, including quasars, produce their enormous jets extending over intergalactic proportions. The same particle slinging almost certainly occurs in all black-hole systems, though with much greater power earlier in the universe,” Melia said.

Only 31 percent of the 222,000 proton trajectories in their sample produced gamma rays within 10 light years of the black hole, Ballantyne said. The other 69 percent escape to greater distances, where presumably they, too, will interact in gamma ray-generating collisions.

“Astronomers do, indeed, observe a glow of very-high energy gamma-rays from the inner regions of the galaxy,” Ballantyne said. “It’s possible that this emission is also caused by protons accelerated close to the central black hole.”

Ballantyne holds UA’s Theoretical Astrophysics Program Prize Postdoctoral Fellowship. The university’s Theoretical Astrophysics Program, organized in 1985, is an interdisciplinary program of the UA departments of physics, astronomy and planetary sciences.

From University of Arizona

January 27, 2007

NASA-Backed Team Developing Sensor to Check for Life on Mars

Filed under: Space — travel @ 2:26 pm

NASA-funded researchers are refining a tool that could not only check for the faintest traces of life’s molecular building blocks on Mars, but could also determine whether they have been produced by anything alive.

The instrument, called Urey: Mars Organic and Oxidant Detector, has already shown its capabilities in one of the most barren climes on Earth, the Atacama Desert in Chile. The European Space Agency has chosen this tool from the United States as part of the science payload for the ExoMars rover planned for launch in 2013. Last month, NASA selected Urey for an instrument-development investment of $750,000.

The European Space Agency plans for the ExoMars rover to grind samples of Martian soil to fine powder and deliver them to a suite of analytical instruments, including Urey, that will search for signs of life. Each sample will be a spoonful of material dug from underground by a robotic drill.

“Urey will be able to detect key molecules associated with life at a sensitivity roughly a million times greater than previous instrumentation,” said Dr. Jeffrey Bada of Scripps Institution of Oceanography at the University of California, San Diego. Bada is the principal investigator for an international team of scientists and engineers working on various components of the device.

To aid in interpreting that information, part of the tool would assess how rapidly the environmental conditions on Mars erase those molecular clues.

Dr. Pascale Ehrenfreund of the University of Leiden in the Netherlands, said, “The main objective of ExoMars is to search for life. Urey will be a key instrument for that because it is the one with the highest sensitivity for organic chemicals.” Ehrenfreund, one of two deputy principal investigators for Urey, coordinates efforts of team members from five other European countries.

Urey can detect several types of organic molecules, such as amino acids, at concentrations as low as a few parts per trillion.

All life on Earth assembles chains of amino acids to make proteins. However, amino acids can be made either by a living organism or by non-biological means. This means it is possible that Mars has amino acids and other chemical precursors of life but has never had life. To distinguish between that situation and evidence for past or present life on Mars, the Urey instrument team will make use of the knowledge that most types of amino acids can exist in two different forms. One form is referred to as “left-handed” and the other as “right-handed.” Just as the right hand on a human mirrors the left, these two forms of an amino acid mirror each other.

Amino acids from a non-biological source come in a roughly 50-50 mix of right-handed and left-handed forms. Life on Earth, from the simplest microbes to the largest plants and animals, makes and uses only left-handed amino acids, with rare exceptions. Comparable uniformity — either all left or all right — is expected in any extraterrestrial life using building blocks that have mirror-image versions because a mixture would complicate biochemistry.

“The Urey instrument will be able to distinguish between left-handed amino acids and right-handed ones,” said Allen Farrington, Urey project manager at NASA’s Jet Propulsion Laboratory, which will build the instrument to be sent to Mars.

If Urey were to find an even mix of the mirror-image molecules on Mars, that would suggest life as we know it never began there. All-left or all-right would be strong evidence that life now exists on Mars, with all-right dramatically implying an origin separate from Earth life. Something between 50-50 and uniformity could result if Martian life once existed, because amino acids created biologically gradually change toward an even mixture in the absence of life.

The 1976 NASA Viking mission discovered that strongly oxidizing conditions at the Martian surface complicate experiments to search for life. The Urey instrument has a component, called the Mars oxidant instrument, for examining those conditions.

NASA-BACKED TEAM DEVELOPING SENSOR TO CHECK FOR LIFE ON MARSINSTRUMENT’S NAME PAYS TRIBUTE TO SCIENTIST

A 1953 experiment that involved making chemical building blocks of life was one major achievement of the scientist from whom the Urey instrument takes its name.

Dr. Harold Urey (1893-1981) [link to http://orpheus.ucsd.edu/speccoll ] and Dr. Stanley Miller, while at the University of Chicago, simulated a hypothetical step in the evolution of life by using electric sparks to convert a mixture of simpler ingredients — water, ammonia, methane and hydrogen — into amino acids and other organic chemicals.

Unlike the amino acids produced by living organisms, amino acids produced by the Miller-Urey experiment and by other non-biological reactions are an even mixture of right-handed and left-handed forms. The Urey instrument for Mars will use this difference to assess whether any amino acids found on Mars are evidence for life.

Harold Urey’s long career included many accomplishments. He won the Nobel Prize for Chemistry in 1934 for the discovery of deuterium, the heavy isotope of hydrogen. Beginning in 1958, he helped build a strong chemistry program at the University of California, San Diego, now the home instruction of the principal investigator for the Urey instrument, Dr. Jeffrey Bada.

The oxidant instrument has microsensors coated with various chemical films. “By measuring the reaction of the sensor films with chemicals present in the Martian soil and atmosphere, we can establish if organisms could survive and if evidence of past life would be preserved,” said Dr. Richard Quinn, a co-investigator on Urey from the SETI Institute, Mountain View, Calif., who also works at NASA Ames Research Center, Moffett Field, Calif.”In order to improve our chances of finding chemical evidence of life on Mars, and designing human habitats and other equipment that will function well on Mars’ surface, we need to improve our understanding of oxidants in the planet’s surface environment,” said Dr. Aaron Zent, a Urey co-investigator at NASA Ames.

A Urey component called the sub-critical water extractor handles the task of getting any organic compounds out of each powdered sample the ExoMars rover delivers to the instrument. “It’s like an espresso maker,” explained JPL’s Dr. Frank Grunthaner, a deputy principal investigator for Urey. “We bring the water with us. It is added to the sample, and different types of organic compounds dissolve into the liquid as the temperature increases. We keep it under pressure the whole time.”

The dissolved compounds are highly concentrated by stripping away water in a tiny oven. Then a detector checks for fluorescent glowing, which would indicate the presence of amino acids, some components of DNA and RNA, or other organic compounds that bind to a fluorescing chemical added by the instrument.

A Urey component called the micro-capillary electrophoresis unit has the critical job of separating different types of organic compounds from one another for identification, including separation of mirror-image amino acids from each other. “We have essentially put a laboratory onto a single wafer,” said Dr. Richard Mathies of the University of California, Berkeley, a Urey co-investigator. The device for sending to Mars will be a small version incorporating this detection technology, which is already in use for biomedical procedures such as law-enforcement DNA tests and checking for hazardous microbes.

Switzerland will provide electronics design and packaging expertise for Urey. Micro-Cameras and Space Exploration S.A., Neuchatel, will collaborate with JPL and the European Space Agency to accomplish this significant contribution to the heart of the instrument. Dr. Jean-Luc Josset, Urey co-investigator at the University of Neuchatel will coordinate this effort and help provide detector selection and support. JPL is a division of the California Institute of Technology in Pasadena.

From NASA

January 26, 2007

Arctic Heat Wave Stuns Climate Change Researchers

Filed under: Energy and Environment — travel @ 9:02 pm

Unprecedented warm temperatures in the High Arctic this past summer were so extreme that researchers with a Queen’s University-led climate change project have begun revising their forecasts.

“Everything has changed dramatically in the watershed we observed,” reports Geography professor Scott Lamoureux, the leader of an International Polar Year project announced yesterday in Nunavut by Indian and Northern Affairs Minister Chuck Strahl. “It’s something we’d envisioned for the future – but to see it happening now is quite remarkable.”

One of 44 Canadian research initiatives to receive a total of $100 million (IPY) research funding from the federal government, Dr. Lamoureux’s new four-year project on remote Melville Island in the northwest Arctic brings together scientists and educators from three Canadian universities and the territory of Nunavut. They are studying how the amount of water will vary as climate changes, and how that affects the water quality and ecosystem sustainability of plants and animals that depend on it.

The information will be key to improving models for predicting future climate change in the High Arctic, which is critical to the everyday living conditions of people living there, especially through the lakes and rivers where they obtain their drinking water.

Other members of the research team include, from the Queen’s Geography Department: Paul Treitz, Melissa Lafreniere and Neal Scott; Myrna Simpson and Andre Simpson from U of T; and Pierre Francus from INRS-ETE, Quebec. Linda Lamoureux of Kingston’s Martello School will work with the scientists to develop learning tools for schools in the north.

From their camp on Melville Island last July, where they recorded air temperatures over 20ºC (in an area with July temperatures that average 5ºC), the team watched in amazement as water from melting permafrost a metre below ground lubricated the topsoil, causing it to slide down slopes, clearing everything in its path and thrusting up ridges at the valley bottom “that piled up like a rug,” says Dr. Lamoureux, an expert in hydro-climatic variability and landscape processes. “The landscape was being torn to pieces, literally before our eyes. A major river was dammed by a slide along a 200-metre length of the channel. River flow will be changed for years, if not decades to come.”

Comparing this summer’s observations against aerial photos dating back to the 1950s, and the team’s monitoring of the area for the past five years, the research leader calls the present conditions “unprecedented” in scope and activity. What’s most interesting, he says, is that their findings represent the impact of just one exceptional summer.

“A considerable amount of vegetation has been disturbed and we observed a sharp rise in erosion and a change in sediment load in the river,” Dr. Lamoureux notes. “With warmer conditions and greater thaw depth predicted, the cumulative effect of this happening year after year could create huge problems for both the aquatic and land populations. This kind of disturbance also has important consequences for existing and future infrastructure in the region, like roads, pipelines and air strips.”

If this were to occur in more inhabited parts of Canada, it would be “catastrophic” in terms of land use and resources, he continues. “It would be like taking an area the size of Kingston and having 15 per cent of it disappear into Lake Ontario.”

The Queen’s-led project is working with other IPY research groups including: Arctic HYDRA, an international group investigating the impact of climate change on water in the Arctic; Science Pub, a Norwegian group working on broad research from science to public education about the impacts of global warming; and CiCAT, a University of British Columbia-led group of 48 researchers investigating the impacts of climate change on tundra vegetation.

International Polar Year (IPY) is the largest-ever international program of coordinated scientific research focused on the Arctic and Antarctic regions and the first in 50 years.

From http://qnc.queensu.ca

Drop in Arctic Sea Ice Raises Questions

Filed under: Energy and Environment — travel @ 8:58 pm

Drop in Arctic Sea Ice Raises Questions

Melting Arctic sea ice has shrunk to a 29-year low, significantly below the minimum set in 2005, according to preliminary figures from the National Snow and Ice Data Center, part of the University of Colorado at Boulder. NASA scientists, who have been observing the declining Arctic sea ice cover since the earliest measurements in 1979, are working to understand this sudden speed-up of sea ice decline and what it means for the future of Earth’s northern polar region.

“The decline in the amount of thick ice that survives the summer melt season this year is quite remarkable,” said Josefino C. Comiso, senior scientist at NASA’s Goddard Space Flight Center, Greenbelt, Md. “The extent of this ‘perennial’ sea ice and the area it covers are both nearly 38 percent lower than average. Compared to the record low in 2005, the extent and area are 24 percent and nearly 26 percent lower this year, respectively.”

“From what we know of how Arctic sea ice behaves after nearly 30 years of continuous satellite observations, this kind of drop in sea ice usually takes more than three years to happen. The rapid trend of the perennial ice previously reported in 2002 appears now to be in an accelerated mode,” Comiso observed.

Because Arctic ice cover varies so much year to year, it can be dangerous to look at any one year and draw too much of a conclusion from it,” said Waleed Abdalati, head of Goddard’s Cryospheric Sciences Branch. “But this year, the amount of ice is so far below that of previous years that it really is cause for concern. The trend in decreasing ice cover seems to be getting stronger and stronger as time goes on.”

NASA developed the original capability to observe the extent and concentration of sea ice from space using passive microwave sensors. More recently, NASA launched an advanced microwave instrument in 2002 — the Advanced Microwave Scanning Radiometer (AMSR-E) on the Aqua satellite — that provides a view of sea ice dynamics in greater detail than has ever been seen before. Researchers use this information to study polar bear habitats and the unique movements of sea ice from season to season. AMSR-E is a joint project of NASA and the National Space Development Agency of Japan.

The accelerating decline in sea ice may be due to changes in climate brought on by the lack of sea ice itself, Comiso believes. “When there is less sea ice in the summer, the Arctic Ocean receives more heat. The warmer water makes it harder for the ice to recover in the winter, and, therefore, there is a higher likelihood that sea ice will retreat farther during the summer. This process repeats itself year after year,” Comiso said.

“The longer this process continues, the less likely recovery becomes,” Abdalati believes. “The implications on global climate are not well known, but they have the potential to be quite large, since the Arctic ice cover exhibits a tremendous influence on our climate. It really is imperative that we try to understand the interactions between the ice, ocean and atmosphere. And satellites hold the key to developing this understanding.”

Current satellites, however, can map sea ice in two dimensions, but it is much more difficult to find out how the thickness of the ice contributes to the change in the total volume of the ice. NASA’s ICESat spacecraft (Ice, Cloud, and land Elevation Satellite), launched in 2003, with the primary goal of determining how much ice sheets are contributing to sea-level rise. ICESat is also collecting data that enables scientists to make estimates of sea ice thickness with unprecedented detail.

“What we need to truly understand the interaction of the ice, ocean and atmosphere in the Arctic is sea ice thickness information,” said Abdalati. “The new capability we have with ICESat is expected to be extended into the next decade based on recent recommendations by the National Research Council for a follow-on mission. Ultimately, like the 29-year record we have now of sea ice cover, a long-term ice thickness record will help scientists understand these complex interactions and what the changes in the ice cover will mean to the ecology of the Arctic and to life on Earth.”

The Evolution of a Galaxy

Filed under: Space — travel @ 7:20 pm

In the early 1900s, Edwin Hubble made the startling discovery that our Milky Way galaxy is not alone. It is just one of many galaxies, or “island universes,” as Hubble dubbed them, swimming in the sea of space.

Now, a century later, NASA’s Galaxy Evolution Explorer is helping piece together the evolution of these cosmic species. Since its launch in 2003, the mission has surveyed tens of thousands of galaxies in ultraviolet light across nine billion years of time. The results provide new, comprehensive evidence for the “nurture” theory of galaxy evolution, which holds that the galaxies first described by Hubble – the elegant spirals and blob-like ellipticals — are evolutionarily linked.

According to this “nurture” theory, a typical young galaxy begins life as a spiral that is actively churning out stars. Over time, the spiral might merge with another spiral or perhaps an irregular-shaped galaxy, before kicking out a few more bursts of newly minted stars. Eventually, the galaxy slows down its production of stars and settles into later life as an elliptical.

“Our data confirm that all galaxies begin life forming stars,” said Chris Martin, the principal investigator for the Galaxy Evolution Explorer at the California Institute of Technology in Pasadena, Calif. “Then through a combination of mergers, fuel exhaustion and perhaps suppression by black holes, the galaxies eventually stop producing stars.”

When astronomers talk about galaxies today, they tend to refer to them by their color, either blue or red, instead of by their shape. Most blue galaxies are smaller spirals or irregulars, and most red galaxies are larger ellipticals, though there are some exceptions.

Why color-code the galaxies? Their color indicates how actively they are making new stars. Younger stars shine in ultraviolet or blue light, so galaxies that appear blue are busily producing stars. Older stars emit infrared or red light, so galaxies that look red have shut down their star-making factories. Roughly half of all galaxies are blue and half are red.

Scientists have long postulated that blue galaxies grow up to become red. They proposed that something happens to the blue galaxies to cause them to run out of star-making material, or gas, and mature into the passive red ones. For this “nurture” theory to be true, there should be a population of “teenage” galaxies in the process of transitioning from blue to red, or young to old. But such a cosmic metamorphosis should take billions of years. How can astronomers, with a significantly shorter lifespan, study a process that takes that long?

One solution is to look at lots and lots of galaxies. Imagine a hypothetical alien trying to figure out how and if humans age from only a handful of snapshots showing people of different ages. The aliens might assume that little people grow into big ones, but they could better piece together the life of a typical human if they could look through boxes and boxes of photographs.

The Galaxy Evolution Explorer was designed to provide astronomers with just such a massive portfolio of galaxies. Its troves of data have allowed scientists to find a significant number of teenage galaxies – and thus proof that youthful spiral, or blue, galaxies will eventually grow up to become the elderly elliptical, or red, galaxies.

“The nurture theory of galaxy evolution predicted that there would be galaxies in transition,” said Martin. “Finding these galaxies required ultraviolet light, because they really stand out at this wavelength. And because they are rare, we had to look at many. The Galaxy Evolution Explorer allowed us to do this.”

Visible-light data from the Sloan Digital Sky Survey also helped to establish the age of the teenage galaxies and the rates at which they are running out of star-making fuel. These findings suggest that some of the young galaxies are ripening into old age quickly, while others are leisurely strolling into their golden years.

Evidence for the “nurture” theory of galaxy evolution can be found in a report in the Astrophysical Journal. Martin is the lead author.

January 24, 2007

What Would You Pay to Go Into Space?

Filed under: Transportation — travel @ 12:52 pm

When Mark Easterfield heard Virgin Galactic was offering flights into space for private travelers two years ago, he took his wife Christine down to their local pub in Cambridge, England, and popped the question: Would she go with him? It took a few pints, but she said yes. “What’s great about Virgin is it’s not the classic astronaut in a space suit. The point is to make it simple so regular people can go into space,” says Christine. “I want to look at the stars. I don’t want to study astrophysics.”

Mark, 53, and Christine, 45, are typical of the first group — dubbed The Founders — who have plunked down $200,000 each to fly into space with Galactic, which hopes to begin operations by 2009. (Branson is still taking deposits of $100,000 to $175,000 for travelers who want to go during the first year.) About a dozen of the aspiring astronauts gathered late November on Necker Island, the private island owned by Virgin Galactic’s boss, Richard Branson, in the British Virgin Islands. I went expecting to meet a bunch of Richie Rich types just looking for a thrill ride. Instead, I found a group of hardy pioneers, millionaires sure, but idealists who dreamed as kids of going into space. Mark, for instance, grew up during the Apollo years, but got rich from an IPO of his software-mapping firm. Now he’s back to his first love. “It’s not the thrill of acceleration for me,” he says. “It’s the experience of looking down to see the Earth, the experience of zero gravity. It would be crazy not to do it.”

“It’s gonna be simpler than I thought,” agrees Ed Holliday, a 62-year-old hedge fund wholesaler from Laguna Niguel, California. “We’re not required to be astronauts, like Steve Austin, the Six Million Dollar Man.” Actually, it’s a two-way street. Virgin Galactic must find out before blast-off how people in their 50s, 60s and 70s — those most able to afford it — can cope with the stress of space travel. “To be commercial viable and safe, we need data on the way people react to g forces and the psychological experience of going into space. We don’t know that yet,” says Alex Tai, Galactic’s chief of operations — and the man who will pilot first Virgin’s first spaceship. One possibility is a ride in a centrifuge to see how passengers will react to the g forces. For now, however, there aren’t a lot of requirements other than deep pockets.

A number of the Founders were struck at how open Branson and the legendary aircraft designer Burt Rutan have been, inviting them to Rutan’s closed shop out in the Mojave Desert, to the Virgin Galactic launch in New York, and yes, to Branson’s private island. “Richard can carry on research until 2012 as far as I’m concerned. It’s such fun,” says John Goodwin, a 62-year-old retired candy wholesaler from England, who talked while his fellow travelers played tennis in the rain. Goodwin had visited Rutan’s workshop. “There he is, answering your questions. We’ve got these seats here, he says. How do YOU want them? I didn’t realize when we come back from space, we’re going to be hitting over 6 gs — six times our body weight. You can’t be sitting upright. You’d black out. You’ve got to lie down and Rutan’s designed a seat to achieve that objective.”

Safety is paramount for the new industry. The space pioneers know they are on borrowed time. In 2004 President Bush signed a law that basically gives them until 2012 to establish standards without the onerous rule-making of the 70-year-old airline industry. This month, the Federal Aviation Administration will issue guidelines for crew and passengers on spaceships. One bad accident and the door to space could be slammed shut. Rutan notes that the risk of dying on early planes was one in 6,000. Today, it’s one in several million. He’s not going to fly until he’s sure today’s spaceships are as safe as early planes, he says. “This isn’t something for crazy avant-garde adventurers. This is not an Everest climb. I don’t think Richard Branson would be comfortable thinking this is a long shot because he is already selling tickets.”

Many of the Founders, in fact, trace their desire to go into space to Neil Armstrong’s walk on the moon in 1969. P.J. King was a kid, living in western Ireland, admiring the sky one night when his older brother started pointing out Orion and the constellations. “I said that’s cool. We should go there. And my big brother says, you can’t go there! I was angry and yelled, ‘But I saw it on TV! They went to the moon’.” Now 38 and living in Dublin, he laughs at the memory, but feels bad about not using his degree in astronautics and space engineering. “Next October will be 50 years since Sputnik went up,” he says in disgust. “This is not just an opportunity to send people 100 or so kilometers (62 miles) into the sky and to have a good time for 10 minutes for a lot of money,” he says. “If we get it right, it will be the start of something extraordinary. It will open the gateway to a lot of innovation in space travel.”

The Founders have, in fact, become quite “evangelical” about space, says Londoner Trevor Beattie, a self-described “space nut” who has a scrapbook from his youth of the Armstrong’s moon walk and the Apollo 13. “You’ll get a sense of wonderment from everybody here,” says the 47-year-old ad man. “You’ve got a bunch of believers who are going to make this happen. It’s a lifelong dream for people.” David Horowitz, a 55-year-old investment manager from Irvine, California, couldn’t agree more. “It’s changed me. We’re doing things we should have been doing 40 years ago in space. That’s Burt’s vision and Richard’s vision — get a bunch of people up there and the perception will change.”

From Time

January 23, 2007

Herpes drug helps control HIV

Filed under: Bioscience and Medicine — travel @ 11:18 pm

Treating women who are infected with both the HSV-2 and HIV viruses with anti-herpes treatment can reduce the amount of HIV in the blood and genital secretions, according to the results of a trial published today in the New England Journal of Medicine.

A collaborative group of scientists from the Centre Muraz (Burkina Faso), the University of Montpellier (France) and the London School of Hygiene & Tropical Medicine (UK) carried out the trial among women co-infected with the human immuno-deficiency virus (HIV) and the virus that causes genital herpes (HSV-2) in Burkina Faso. The results showed that having the herpes virus increased the replication of HIV, and also revealed that the quantity of HIV in the blood and in the vagina was reduced by continuous anti-herpes treatment over 3 months.

These findings open new avenues for the prevention of HIV transmission and for the management of patients co-infected by the two viruses.

In 2005, an estimated 4.1 million people were newly infected with HIV, mostly through heterosexual intercourse1. This alarming number of infections highlights the urgent need to intensify and expand proven prevention methods, and further, to identify and implement new methods of HIV prevention.

A number of observational studies have indicated that HSV-2 enhances the risk of HIV-1 acquisition by around three-fold2. HSV-2 infection may also increase HIV-1 infectiousness by disrupting the genital mucosa and increasing the levels of HIV in the genital tract3, allowing easier transmissibility of the virus. In addition, the HIV viral load in the blood of HIV-1 infected patients increases, at least temporarily, during episodes of HSV reactivation.

Lead author Dr. Nicolas Nagot, of the London School of Hygiene & Tropical Medicine (LSHTM), explains: ‘Behavioural interventions are not always successful, as knowledge does not necessarily translate into sexual behaviour change. Therefore, innovative methods that target the biological susceptibility of individuals to acquire or transmit HIV are also required. A number of options to prevent HIV transmission are currently being investigated, including the role of vaginal microbicides, pre-exposure HIV prophylaxis, male circumcision, and – in the future – an HIV vaccine.’

‘The results of the trial are striking’, he adds. ‘They show that valacyclovir significantly reduces the frequency and quantity of HIV detectable in genital secretions and, in addition, reduces the quantity of HIV in the plasma. As expected, there was also dramatic reduction in the detection of symptomatic and asymptomatic presence of HSV-2. The effects appeared to gradually increase over the 3 month follow-up period, with no sign of abating.’

These results indicate a new way to possibly reduce the sexual transmission of HIV from already infected individuals to their partners, since the frequency and quantity of HIV in the female genital tract are closely related to the transmission of the virus.

The findings will need to be confirmed by further research, and there is already a large ongoing trial that is measuring direct transmission of HIV between discordant couples in several sites worldwide.

Dr Philippe Mayaud, one of Dr Nagot’s colleagues at the LSHTM concludes: ‘Our results have important potential implications for public health and clinical practice, as HSV-2 control could become a new form of HIV prevention targeting HIV-infected individuals, as well as providing clinical benefits. Importantly, an HSV vaccine that would either prevent HSV infection or diminish the clinical and sub-clinical manifestations of HSV with a similar efficacy on HIV as HSV suppressive therapy, would represent a long-lasting form of HIV prevention. The development and evaluation of an HSV vaccine should rank high on the international research agenda.’

Gareth Thomas, UK Minister for International Development, whose department DFID has provided supplementary funding for the research, said: “These exciting initial findings demonstrate why research into reducing HIV/ AIDS transmission is such a vital element of the fight against the disease. The UK Government has pledged to spend £1.5 billion tackling HIV/AIDS in developing countries between 2005 and 2008. We will follow the next stages of this research with interest.”

For further information, or to contact any of the study authors, please contact:
Philippe Mayaud, Clinical Research Unit, Department of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine, London WC1E 7HT; tel 207 927 2291; email: philippe.mayaud@lshtm.ac.uk

Notes to Editors:
1. Herpes simplex virus type-2 (HSV-2), a sexually transmitted virus, is one of the most common pathogens worldwide4. HSV-2 is a lifelong infection and is found in nearly 80% of HIV-infected patients. Once acquired, the virus cycles between latency (hidden in nerves), asymptomatic genital excretion of the virus (’shedding’), and clinical reactivations that can produce painful ulcers in and around the genitalia. The herpes virus can be targeted by specific HSV-2 antiviral drugs such as acyclovir, valacyclovir or famciclovir, which are relatively affordable medications with few side effects, and to which the herpes virus rarely becomes resistant. These drugs are effective in preventing the recurrence of disease and in curbing the transmission of HSV-2 from infected to uninfected partners5.

2. In 2001, an international workshop organised by WHO, UNAIDS and LSHTM called for randomised controlled trials of HSV-2 therapy to definitely establish a causal relationship between HSV-2 and HIV-1 infectivity and acquisition6. We have now completed the first two randomised placebo-controlled trials of herpes suppressive treatment (with valacyclovir at a dose of 500 mg twice daily for 3 months) among HIV-infected individuals. The studies were conducted in Burkina Faso among women who were dually seropositive for HIV and HSV-2. In the first trial (ANRS1285a) published in today’s issue of the New England Journal of Medicine7, we report on the impact of HSV suppressive treatment on plasma and genital HIV-1 levels among women who did not require ART and who did not require a treatment for their HSV infection (they had less than 6 episodes per year). In the companion trial (ANRS1285b), which has been published recently in AIDS8, we reported the impact of herpes suppressive therapy on plasma and genital HIV-1 levels among women who were taking highly active antiretroviral therapy (HAART).

The ANRS 1285b trial was conducted among 60 women who had been taking HAART for at least 4 months. This trial showed that valacyclovir had an additional impact on the residual shedding of HIV-1 despite good systemic control of the virus. This supports an effect of HSV-2 on independent mucosal HIV-1 replication – an important contribution to the HSV/HIV co-activation hypothesis.

Note on funding and sponsorship
This research was sponsored by France’s Agence Nationale de Recherches sur le Sida et les Hepatites (ANRS), with supplementary financial support from the United Kingdom’s Department for International Development (DFID).

The ANRS, created in 1992 to specifically respond to the many scientific challenges posed by the extension of the HIV/AIDS pandemic, coordinates research activities that span several disciplines from fundamental research, to clinical research, public health and socio-anthropological research.

DFID has been funding research on HIV/AIDS through a series of research programmes formerly called ‘Knowledge Programmes’ and currently ‘Research Programme Consortia’. The purpose of the current LSHTM-based Consortium on Sexual and Reproductive Health and HIV is to strengthen the evidence base to enable policy makers to identify and prioritise interventions that will improve reproductive and sexual health and reduce HIV incidence among economically poor populations in Africa and Asia; and to ensure that the research results are made available to policy makers at national and international levels in an intelligible and relevant form.

Footnotes:

1 – UNAIDS. 2006 Report on the Global AIDS Epidemic. Geneva, 2006.

2 – We have published several accounts of worldwide epidemiology: e.g. Weiss HA. Herpes 2004; 11:24A-35A; Cowan FM, et al. Sex Transm Infect 2003; 79; 286-290.

3 – Corey L, et al. N Engl J Med. 2004; 350(1): 11-20.

4 – Meta-analysis performed by our group: Freeman EE, et al. AIDS 2006; 20: 73-83.

5 – Several accounts of this in our work: eg. Mbopi-Keou F-X, et al. J Infect Dis 2000; 182: 1090-6.

6 – World Health Organisation. Herpes simplex virus type 2: Programmatic and research priorities in developing countries. Report of a WHO/UNAIDS/LSHTM workshop (London, 14-16 February 2001). Document WHO/HIV AIDS/2001.05. Geneva: WHO, 2001.

7 – Nicolas Nagot, Abdoulaye Ouedraogo, Vincent Foulongne, Issouf Konate, Helen A. Weiss, Laurence Vergne, Marie-Christine Defer, Didier Djagbare, Anselme Sanon, Jean-Baptiste Andonaba, Pierre Becquart, Michel Segondy, Roselyne Vallo, Adrien Sawadogo, Philippe Van de Perre, and Philippe Mayaud for the ANRS 1285 Study Group. Reduction of HIV-1 RNA Levels with Therapy to Suppress Herpes Simplex Virus. New Engl J Med 2007;356 (8): 790-9.

8 – Abdoulaye Ouedraogo, Nicolas Nagot, Laurence Vergne, Issouf Konate, Helen A. Weiss, Marie-Christine Defer, Vincent Foulongne, Anselme Sanon, Jean-Baptiste Andonaba, Michel Segondy, Philippe Mayaud and Philippe Van de Perre. Impact of suppressive herpes therapy on genital HIV-1 RNA among women taking antiretroviral therapy: a randomized controlled trial. AIDS 2006; 20: 2305-13.

From London School of Hygiene & Tropical Medicine

NASA’s Spitzer First to Crack Open Light of Faraway Worlds

Filed under: Space — travel @ 11:16 pm

NASA’s Spitzer Space Telescope has captured for the first time enough light from planets outside our solar system, known as exoplanets, to identify molecules in their atmospheres. The landmark achievement is a significant step toward being able to detect possible life on rocky exoplanets and comes years before astronomers had anticipated.

“This is an amazing surprise,” said Spitzer project scientist Dr. Michael Werner of NASA’s Jet Propulsion Laboratory, Pasadena, Calif. “We had no idea when we designed Spitzer that it would make such a dramatic step in characterizing exoplanets.”

Spitzer, a space-based infrared telescope, obtained the detailed data, called spectra, for two different gas exoplanets. Called HD 209458b and HD 189733b, these so-called “hot Jupiters” are, like Jupiter, made of gas, but orbit much closer to their suns.

The data indicate the two planets are drier and cloudier than predicted. Theorists thought hot Jupiters would have lots of water in their atmospheres, but surprisingly none was found around HD 209458b and HD 189733b. According to astronomers, the water might be present but buried under a thick blanket of high, waterless clouds.

Those clouds might be filled with dust. One of the planets, HD 209458b, showed hints of tiny sand grains, called silicates, in its atmosphere. This could mean the planet’s skies are filled with high, dusty clouds unlike anything seen around planets in our own solar system.

“The theorists’ heads were spinning when they saw the data,” said Dr. Jeremy Richardson of NASA’s Goddard Space Flight Center, Greenbelt, Md.

“It is virtually impossible for water, in the form of vapor, to be absent from the planet, so it must be hidden, probably by the dusty cloud layer we detected in our spectrum,” he said. Richardson is lead author of a Nature paper appearing Feb. 22 that describes a spectrum for HD 209458b.

In addition to Richardson’s team, two other groups of astronomers used Spitzer to capture spectra of exoplanets. A team led by Dr. Carl Grillmair of NASA’s Spitzer Science Center at the California Institute of Technology in Pasadena, Calif., observed HD 189733b, while a team led by Dr. Mark R. Swain of JPL focused on the same planet in the Richardson study, and came up with similar results. Grillmair’s results will be published in the Astrophysical Journal Letters. Swain’s findings have been submitted to the Astrophysical Journal Letters.

A spectrum is created when an instrument called a spectrograph splits light from an object into its different wavelengths, just as a prism turns sunlight into a rainbow. The resulting pattern of light, the spectrum, reveals “fingerprints” of chemicals making up the object.

Until now, the only planets for which spectra were available belonged in our own solar system. The planets in the Spitzer studies orbit stars that are so far away, they are too faint to be seen with the naked eye. HD 189733b is 370 trillion miles away in the constellation Vulpecula, and HD 209458b is 904 trillion miles away in the constellation Pegasus. That means both planets are at least about a million times farther away from us than Jupiter. In the future, astronomers hope to have spectra for smaller, rocky planets beyond our solar system. This would allow them to look for the footprints of life — molecules key to the existence of life, such as oxygen and possibly even chlorophyll.

“With these new observations, we are refining the tools that we will one day need to find life elsewhere if it exists,” said Swain. “It’s sort of like a dress rehearsal.”

Spitzer was able to tease out spectra from the feeble light of the two planets through what is known as the “secondary eclipse” technique. In this method — first used by Spitzer in 2005 to directly detect the light from an exoplanet for the first time ( http://www.spitzer.caltech.edu/Media/releases/ssc2005-09/index.shtml ) — a so-called transiting planet is monitored as it circles behind its star, temporarily disappearing from our Earthly point of view. By measuring the dip in infrared light that occurs when the planet disappears, Spitzer can learn how much light is coming solely from the planet. The technique will work only in infrared wavelengths, where the planet is brighter than in visible wavelengths and stands out better next to the overwhelming glare of its star.

In the new studies, Spitzer’s spectrograph, which measures infrared light at a range of wavelengths, stared at the two transiting planets as they orbited their stars. This allowed the astronomers to subtract the spectra of the stars from the spectra of the planets plus their stars to obtain spectra of the planets alone.

“When we first set out to make these observations, they were considered high risk because not many people thought they would work,” said Grillmair. “But Spitzer has turned out to be superbly designed and more than up to the task.”

Previous observations of HD 209458b by NASA’s Hubble Space Telescope revealed individual elements, such as sodium, oxygen, carbon and hydrogen, that bounce around the very top of the planet, a region higher up than that probed in the Spitzer studies and a region where molecules like water would break apart. To do this, Hubble measured changes in the light from the star, not the planet, as the planet passed in front. The observations indicated less sodium than predicted, which again supports the idea that the planet is socked in with high clouds.

Astronomers hope to use Spitzer for additional studies of transiting exoplanets, which are those that cross in front of their stars from our point of view. Of the approximately 200 known exoplanets, 14 are transiting. At least three of these in addition to HD 209458b and HD 189733b are candidates for obtaining spectra. Further spectral studies of HD 209458b and HD 189733b will also yield more information about the planets’ atmospheres.

NASA’s Jet Propulsion Laboratory, Pasadena, Calif., manages the Spitzer Space Telescope mission for NASA’s Science Mission Directorate, Washington. Science operations are conducted at the Spitzer Science Center at the California Institute of Technology, also in Pasadena. Caltech manages JPL for NASA. Spitzer’s infrared spectrograph was built by Cornell University, Ithaca, N.Y. Its development was led by Dr. Jim Houck of Cornell.

For artist’s concepts and more information, visit http://www.nasa.gov/spitzer and www.spitzer.caltech.edu/Media

Study to Look at Aspirin as Aid to Conception, Healthy Pregnancy

Filed under: Bioscience and Medicine — travel @ 10:47 pm

Researchers at the University at Buffalo and the University of Utah are beginning a clinical trial to test whether aspirin can improve a woman’s chances of becoming pregnant and of maintaining a pregnancy to term.

UB’s portion of the study is funded by a $2.8 million grant from the National Institute of Child Health and Development.

The trial is aimed at women who have miscarried a pregnancy in the past year.

“In women who have had their first miscarriage, the reasons for losing that pregnancy are in many instances unknown,” said Jean Wactawski-Wende, Ph.D., UB associate professor of social and preventive medicine and principal investigator of the UB clinical center.

“These women generally are advised to try to get pregnant again, but health-care providers can offer limited assistance on any specific actions to take to improve their next pregnancy outcome,” she noted. “If aspirin can help some women become pregnant or maintain a health pregnancy, it will be a critically important finding.

“Aspirin is available, inexpensive and has very few side effects,” she added. “We’re hopeful that this trial could produce an important finding.”

Statistics show that in the United States, 10-15 percent of couples trying to become pregnant are not able to conceive, 15-31 percent of pregnancies that do occur end in miscarriage, and 8-15 percent of pregnancies that continue beyond 20 weeks end in premature birth, putting these infants at risk for increased health problems.

Aspirin has been shown to have beneficial effects in humans, said Wactawski-Wende. “It is an anticoagulant and an anti-inflammatory agent. It may aid in implantation of the egg in the uterine wall, and has potential for producing a positive effect on blood flow to the placenta. It may aid in reducing preeclampsia. This clinical trial provides an opportunity to determine the impact of low-dose aspirin on many pregnancy outcomes.”

The Effects of Aspirin in Gestation & Reproduction trial, or EAGeR, will begin this spring and will continue for five years. The UB center will enroll 535 women. Another 1,070 will be recruited by investigators at the University of Utah, for a total enrollment of 1,600 women.

Participants must be between the ages of 18 and 40, have had one miscarriage in the year prior to entering the study, wish to become pregnant and are not already pregnant when they start the study. All will take 400 micrograms of folic acid (a B vitamin shown to reduce the chance of certain birth defects if started early) plus either an 80 milligram aspirin pill or a placebo pill daily.

The women will come to the UB study clinic twice a month for two months and will be followed for an additional four months in the clinic or by telephone. If they become pregnant they will be followed throughout the pregnancy. Participants will take their study pills daily, maintain daily records and provide both urine and blood samples.

Recruitment will begin shortly. “We are thrilled to be able to conduct this trial in Western New York and offer women in our community the opportunity to take part in this important study,” said Wactawski-Wende.

UB consultants include Richard Brown, Ph.D., Maurizio Trevisan, M.D., Moeen Abu-Sitta, M.D., John Yeh, M.D., Dennis Weppner, M.D., Lawrence Gugino, M.D., Ken Crickard, M.D., and Michael Sullivan, M.D.

The University at Buffalo is a premier research-intensive public university, the largest and most comprehensive campus in the State University of New York. The School of Public Health and Health Professions is one of five schools that constitute UB’s Academic Health Center.

From University at Buffalo

New evidence — Clovis people not first to populate N. America

Filed under: Anthropology — travel @ 10:46 pm

The belief that the Clovis People were the first to populate North America some 11,500 years ago has been widely challenged in recent years, and a Texas A&M University anthropologist has found evidence he says could be the final nail in the coffin for the Clovis first model.

Michael Waters, director of the Center for the Study of the First Americans at Texas A&M, is the lead author of the paper “Redefining the Age of Clovis: Implications for the Peopling of the Americas,” that appears in the Feb. 23 (Friday) issue of Science.

Waters’ paper revises the original dates for the Clovis time period, suggesting that humans likely inhabited the Americas before Clovis, who have long been considered to be the first inhabitants of the New World.

“It was always argued that Clovis represented the first people who came to the Americas,” Waters says. “The new dating that we did indicates that the Clovis Complex ranges from 11,050 to 10,900 radiocarbon years before the present.”

“Slowly but surely, archaeologists have been questioning whether Clovis represents the earliest people to enter the Americas.”

To properly understand the age of Clovis, Waters and co-author Thomas Stafford of Stafford Research Laboratories in Colorado, tested samples from various Clovis sites in an effort to re-date some of what Waters says were poorly dated sites.

Because of technological advances, Waters says that he and Stafford were able to more precisely pinpoint the dates for some of the more than 25 dated Clovis sites that were excavated in North America.

“Many of these radiocarbon dates were run back in the 1960s and 1970s when radiocarbon technology wasn’t what it is today,” says Waters. “Many of the dates obtained from these sites had ranges on them of plus or minus 250 years. We can now get to plus or minus 30 years.”

What Waters and Stafford found when they did their testing were radiocarbon dates that showed the Clovis time range wasn’t as long as had been previously thought. Their tests placed the Clovis time frame between 11,050 radiocarbon years before present to approximately 10,800 radiocarbon years before present.

“It was a surprise,” Waters says of the results. “And I think people are going to be surprised by the dates.”

Waters says those dates show that Clovis was no more than 200 to 400 calendar years long, making it almost impossible for the Clovis people to spread as far as previously thought in such a short time span. They would, at most, have had to be prehistoric jet-setters to cover the ground in this amount of time.

“Once you realize that the Clovis Complex dates much younger than previously thought and that Clovis has a much shorter duration than we thought, you have to ask how could people, in such a short period of time, reach the tip of South America.” Waters says. “It doesn’t make any kind of anthropological sense that these people could have been moving that fast, nor would they have wanted to move that fast. And it seems highly unlikely, given 20 generations, they could have made it that far that quickly.”

To re-date the sites, Waters requested samples for dating from different researchers who had excavated Clovis sites. He then sent the radiocarbon samples to Stafford who put them through a process where the bone is dissolved and bone collagen is extracted.

The collagen was put in a molecular sieve where it worked its way down through the sieve. Once this was complete, Stafford was left with purified amino acids from the bone. The highly chemically-pure sample was processed into a target and dated using an atomic accelerator.

The revised ages that Waters and Stafford obtained overlap dates from a number of North American sites that are technologically and culturally not Clovis sites, further bringing into question whether the Clovis People were the first humans in the Americas.

“The long-range implications of our study is that it will get scientists looking for pre-Clovis evidence with a lot more vigor and thinking differently about Clovis,” Waters says. “This will force us to develop a new model to explain the peopling of the Americas.”

From Texas A&M

Older Posts »

Powered by WordPress